Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)
Applications close Nov 17, 2026
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- Agency
- National Institutes of Health
- Opportunity number
- PAR-25-274
- Posted
- Nov 21, 2024
- Closes
- Nov 17, 2026
- Cost sharing required
- false
About this opportunity
The goal of this notice of funding opportunity (NOFO) is to support feasibility trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) for conditions that have been identified by NCCIH as high-priority research topics. This funding opportunity is intended to support feasibility clinical trials that provide new information that are scientifically necessary for the planning and conduct of a subsequent clinical efficacy or effectiveness study, pragmatic trial, or dissemination and implementation trial within NCCIHs mission. NCCIH expects that applications to this NOFO will describe the planned future clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent competitive full-scale clinical trial. Under this R34, the data collected should be used to fill gaps in scientific knowledge necessary to develop a competitive full-scale clinical trial, including, but not limited to the following: examining feasibility and acceptability of interventions lacking published data; tailoring or adapting the content or structure of an intervention to a specific population, modality, or setting; refining the intervention to determine the most appropriate frequency or duration; determining feasibility of recruitment, retention, and data collection procedures; refining and assessing the feasibility of protocolized multi-component interventions; or examining acceptability and adherence of control conditions. The subsequent full-scale clinical trial should have the potential to make a significant impact on public health. Prior to submitting to this NOFO, applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact person for the science area of the planned application.
Who can apply
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
How to apply
- 1Register your organization
Applications are submitted by your institution, not individuals. Make sure your organization has an active SAM.gov registration (with a UEI) and a Grants.gov account with an Authorized Organization Representative.
- 2Read the full notice
Open the official notice for the complete eligibility rules, review criteria, page limits, and required forms. Applications close Nov 17, 2026.
- 3Download the application package
From the Grants.gov opportunity page, download the package (or apply via your agency's system where required) and prepare each component.
- 4Build and submit
Prepare the budget and narrative, route for institutional sign-off, and submit before the deadline: GrantsManager can track every step for you.
Agency contact: National Institutes of Health · grantsinfo@nih.gov
Details are pulled from Grants.gov and can change, always confirm against the official notice. GrantsManager isn't affiliated with these agencies.
Resources for applying
All NIH grants and resources- Proposal submission checklist
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- NIH modular budget
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- NIH eRA Commons
NIH application status, progress reports (RPPR), and award management.
- SciENcv
Biosketches and Current & Pending (Other) Support documents.
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