Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)
Applications close Jan 7, 2028
Bring this opportunity into GrantsManager
Save it to your pipeline in one click: track the deadline, build the budget, and manage the proposal from draft to award. New here? You'll set up your account in a moment and this opportunity will be waiting.
- Agency
- National Institutes of Health
- Opportunity number
- PAR-25-273
- Posted
- Nov 15, 2024
- Closes
- Jan 7, 2028
- Award ceiling
- $200,000
- Estimated program funding
- $200,000
- Cost sharing required
- false
About this opportunity
This notice of funding opportunity (NOFO) encourages innovative research to develop, improve, characterize, and preserve animal models as well as animal model related biological materials, technologies, and new approach methodologies (NAMs) for studies relevant to human health and disease. This NOFO also seeks projects aimed at improving the diagnosis and control of diseases that could confound or interfere with animal use in biomedical research. The proposed project must have broad applicability to multiple NIH Institutes or Centers (ICs) to align with the NIH-wide mission of the Office of Research Infrastructure Programs (ORIP). The proposed studies must include animal models and explore multiple body systems or multiple categories of diseases. Applications that develop models focused on a specific disease or area of research, or only propose studies primarily relevant to a single NIH IC, will be considered not acceptable to this NOFO and will be withdrawn.
Who can apply
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
How to apply
- 1Register your organization
Applications are submitted by your institution, not individuals. Make sure your organization has an active SAM.gov registration (with a UEI) and a Grants.gov account with an Authorized Organization Representative.
- 2Read the full notice
Open the official notice for the complete eligibility rules, review criteria, page limits, and required forms. Applications close Jan 7, 2028.
- 3Download the application package
From the Grants.gov opportunity page, download the package (or apply via your agency's system where required) and prepare each component.
- 4Build and submit
Prepare the budget and narrative, route for institutional sign-off, and submit before the deadline: GrantsManager can track every step for you.
Agency contact: National Institutes of Health · grantsinfo@nih.gov
Details are pulled from Grants.gov and can change, always confirm against the official notice. GrantsManager isn't affiliated with these agencies.
About the NIH R21 program
A shorter NIH grant for exploratory, high-risk/high-reward work that doesn't yet have extensive preliminary data.
Typical award: Up to 2 years, with combined direct costs normally capped at $275K and no more than $200K in any single year.
Resources for applying
All NIH grants and resources- Proposal submission checklist
A pre-submission checklist for research proposals: solicitation review, internal routing, budget, compliance, and sponsor-system steps to hit the deadline cleanly.
- NIH modular budget
How NIH modular budgets work: the $250,000 threshold, $25,000 modules, consortium F&A, what goes in the personnel, consortium, and additional narrative justifications, and a worked example.
- Reading your Notice of Award
The parts of a Notice of Award that determine what you can spend, when, and what needs prior approval, plus the terms that cause disallowed costs if missed.
- Letter of Support Template for Grant Applications
A free letter of support template for NIH and other research grant applications, with collaborator and consultant versions, what NIH asks letters to include, and how NIH's move to letters of collaboration affects them.
- NIH Data Management and Sharing Plan Template
A free NIH Data Management and Sharing (DMS) Plan template in the updated 2026 format required for due dates on or after May 25, 2026, with every element, word limits, and example answers.
- Budget Justification Template
A free budget justification (budget narrative) template for research grants, organized by the federal R&R budget categories, with example language for personnel, fringe, equipment, travel, other direct costs, subawards, and F&A.
- Grant Application Cover Letter Template
A free cover letter template for NIH grant applications, with when a cover letter is required, what to include, who reads it, and why assignment requests now go on a separate form.
- NIH salary cap 2026
The NIH salary cap for 2026 is $228,000 (Executive Level II, effective January 1, 2026). See the cap by year and calculate the allowable salary and over-the-cap amount at any effort level.
- NIH modular budget
Round direct costs up to $25,000 modules for each budget year, check eligibility for a modular budget (up to $250,000 a year), and total the request with consortium F&A.
- F&A & MTDC calculator
Build the Modified Total Direct Cost base, apply your F&A rate, and see total direct costs, indirect costs, and the full award total, with the usual MTDC exclusions handled.
- Grant burn rate
Compare the share of a grant spent and encumbered with the share of the award period elapsed, see the average monthly burn, the monthly spend needed to finish on budget, and the projected run-out date.
- Grants.gov
Federal grant applications and forms for NIH, USDA, and many others.
- NIH eRA Commons
NIH application status, progress reports (RPPR), and award management.
- SciENcv
Biosketches and Current & Pending (Other) Support documents.
Manage this from draft to award
Start free: track the deadline, budget, and submission in one place.