Cancer Prevention and Control Clinical Trials Planning Grant Program (U34 Clinical Trials Optional)
Applications close Oct 25, 2027
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- Agency
- National Institutes of Health
- Opportunity number
- PAR-25-103
- Posted
- Nov 5, 2024
- Closes
- Oct 25, 2027
- Cost sharing required
- false
About this opportunity
The purpose of this NOFO is to facilitate well planned clinical trials across the cancer prevention and control spectrum aimed at improving prevention/ interception, cancer-related health behaviors, screening, early detection, healthcare delivery, management of treatment-related symptoms, supportive care, and the long-term outcomes of cancer survivors. Although the scientific literature or preliminary data may provide the rationale for conducting a clinical trial, investigators often lack critical information about the study population, accrual challenges, intervention, outcome/ endpoints, data/statistical challenges or operational risks necessary to finalize the trial protocol completely. These information gaps can result in multiple protocol changes before and after trial start-up, leading to the need for additional time and expenses that may prevent study completion. Further, the suitability and feasibility of new trial designs, which minimize infrastructure and reduce costs may need to be tested in the context of a particular intervention, at-risk group, symptom or venue. Preparatory studies may fill information gaps and address unknowns, improving trial design and knowledge of trial feasibility and thus saving NCI time and money.
Who can apply
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
How to apply
- 1Register your organization
Applications are submitted by your institution, not individuals. Make sure your organization has an active SAM.gov registration (with a UEI) and a Grants.gov account with an Authorized Organization Representative.
- 2Read the full notice
Open the official notice for the complete eligibility rules, review criteria, page limits, and required forms. Applications close Oct 25, 2027.
- 3Download the application package
From the Grants.gov opportunity page, download the package (or apply via your agency's system where required) and prepare each component.
- 4Build and submit
Prepare the budget and narrative, route for institutional sign-off, and submit before the deadline: GrantsManager can track every step for you.
Agency contact: National Institutes of Health · grantsinfo@nih.gov
Details are pulled from Grants.gov and can change, always confirm against the official notice. GrantsManager isn't affiliated with these agencies.
Resources for applying
All NIH grants and resources- Proposal submission checklist
A pre-submission checklist for research proposals: solicitation review, internal routing, budget, compliance, and sponsor-system steps to hit the deadline cleanly.
- NIH modular budget
How NIH modular budgets work: the $250,000 threshold, $25,000 modules, consortium F&A, what goes in the personnel, consortium, and additional narrative justifications, and a worked example.
- Reading your Notice of Award
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- Letter of Support Template for Grant Applications
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- NIH Data Management and Sharing Plan Template
A free NIH Data Management and Sharing (DMS) Plan template in the updated 2026 format required for due dates on or after May 25, 2026, with every element, word limits, and example answers.
- Budget Justification Template
A free budget justification (budget narrative) template for research grants, organized by the federal R&R budget categories, with example language for personnel, fringe, equipment, travel, other direct costs, subawards, and F&A.
- Grant Application Cover Letter Template
A free cover letter template for NIH grant applications, with when a cover letter is required, what to include, who reads it, and why assignment requests now go on a separate form.
- NIH salary cap 2026
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- NIH modular budget
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- F&A & MTDC calculator
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- Grants.gov
Federal grant applications and forms for NIH, USDA, and many others.
- NIH eRA Commons
NIH application status, progress reports (RPPR), and award management.
- SciENcv
Biosketches and Current & Pending (Other) Support documents.
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